| http://purl.uniprot.org/citations/17726374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17726374 | http://www.w3.org/2000/01/rdf-schema#comment | "The APC/C(Cdh1) (anaphase promoting complex/cyclosome) targets numerous cell cycle proteins for ubiquitin mediated degradation in late mitosis and G1. The KEN box is one of two major recognition motifs of APC/C(Cdh1) substrates. This motif is however very common and shared by a tenth of the human proteome, the vast majority of which are obviously not APC/C substrates. We have observed that most known functional KEN boxes are followed by a proline residue and show that this proline plays a role in APC/C(Cdh1) specific degradation. This insight can be instrumental for identifying novel APC/C(Cdh1) substrates. We used this KENxP motif to identify human Aurora B and Kid as APC/C(Cdh1) substrates. The degradation of Xenopus XKid at metaphase by APC/C(Cdc20) is essential for chromatid segregation. Human Kid in contrast is degraded later and its APC/C(Cdh1) specific degradation is not required for mitotic progress. It is thus likely that Kid inactivation in G1 takes place both by nuclear sequestration and degradation by the APC/C(Cdh1)."xsd:string |
| http://purl.uniprot.org/citations/17726374 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.6.20.4791"xsd:string |
| http://purl.uniprot.org/citations/17726374 | http://purl.uniprot.org/core/author | "Brandeis M."xsd:string |
| http://purl.uniprot.org/citations/17726374 | http://purl.uniprot.org/core/author | "Mahbubani H."xsd:string |
| http://purl.uniprot.org/citations/17726374 | http://purl.uniprot.org/core/author | "Zur A."xsd:string |
| http://purl.uniprot.org/citations/17726374 | http://purl.uniprot.org/core/author | "Feine O."xsd:string |
| http://purl.uniprot.org/citations/17726374 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17726374 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/17726374 | http://purl.uniprot.org/core/pages | "2516-2523"xsd:string |
| http://purl.uniprot.org/citations/17726374 | http://purl.uniprot.org/core/title | "Human Kid is degraded by the APC/C(Cdh1) but not by the APC/C(Cdc20)."xsd:string |
| http://purl.uniprot.org/citations/17726374 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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