| http://purl.uniprot.org/citations/17760848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17760848 | http://www.w3.org/2000/01/rdf-schema#comment | "Focal disorganization of gap junctional distribution and down-regulation of the major gap junctional protein connexin 43 are typical features of myocardial remodelling in the failing human heart. Increasing evidence indicates that connexin 43 interacts with zonula-occludens-1 (ZO-1), and it has recently been shown that ZO-1 promotes the formation and growth of gap junctional plaques. In the present study, distribution patterns of ZO-1 and connexin 43 were studied in normal and in heart failure patients using double-label immunohistochemistry and confocal microscopy. ZO-1 was found to be co-localized with connexin 43 at intercalated disks. Importantly, in patients with heart failure due to dilated or ischaemic cardiomyopathy, areas of diminished connexin 43 expression were characterized by a markedly reduced ZO-1 staining. Based on these data it is concluded that in patients with heart failure, down-regulation of ZO-1 matches the diminished expression levels of connexin 43, suggesting that ZO-1 plays an important role in gap junction formation and gap junction plaque stability."xsd:string |
| http://purl.uniprot.org/citations/17760848 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1582-4934.2007.00063.x"xsd:string |
| http://purl.uniprot.org/citations/17760848 | http://purl.uniprot.org/core/author | "Kostin S."xsd:string |
| http://purl.uniprot.org/citations/17760848 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17760848 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |
| http://purl.uniprot.org/citations/17760848 | http://purl.uniprot.org/core/pages | "892-895"xsd:string |
| http://purl.uniprot.org/citations/17760848 | http://purl.uniprot.org/core/title | "Zonula occludens-1 and connexin 43 expression in the failing human heart."xsd:string |
| http://purl.uniprot.org/citations/17760848 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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