| http://purl.uniprot.org/citations/17761692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17761692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17761692 | http://www.w3.org/2000/01/rdf-schema#comment | "SerpinB6 (Proteinase inhibitor 6/PI-6) is an intracellular serpin produced by leukocytes, platelets, endothelial cells, keratinocytes and other epithelial cells. It is a potent cathepsin G inhibitor thought to protect monocytes, neutrophils and bystander cells from ectopic cathepsin G during inflammation. Here we show that serpinB6 also inhibits the human serine protease kallikrein-8 (hK8) and that in human and mouse skin, serpinB6 and kallikrein-8 co-localize in differentiated keratinocytes. SerpinB6 inhibits hK8 with an association rate constant (kass) of 1.8 +/- 0.2 x 10(5) M(-1)s(-1) compared to 3.4 +/-0.2 x 10(6) M(-1) s(-1) for the interaction between the mouse orthologue of serpinB6 (SPI3/serpinb6a) and mouse kallikrein-8 (mK8). Molecular modelling suggested that the lower efficiency of the serpinB6/hK8 interaction is partly due to the bulkier P2 methionine residue of serpinB6 compared to the smaller P2 valine in SPI3. Taken together, these results suggest that serpinB6 is a physiologically relevant inhibitor of hK8 in skin. We postulate that serpinB6 protects the intracellular compartment of keratinocytes from ectopic hK8."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.org/dc/terms/identifier | "doi:10.1093/jb/mvm156"xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.org/dc/terms/identifier | "doi:10.1093/jb/mvm156"xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Whisstock J.C."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Whisstock J.C."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Bird P.I."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Bird P.I."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Scott F.L."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/author | "Scott F.L."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/name | "J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/name | "J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/pages | "435-442"xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/pages | "435-442"xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/title | "SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/title | "SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/volume | "142"xsd:string |
| http://purl.uniprot.org/citations/17761692 | http://purl.uniprot.org/core/volume | "142"xsd:string |