| http://purl.uniprot.org/citations/17761849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17761849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17761849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/17761849 | http://www.w3.org/2000/01/rdf-schema#comment | "Methylation of histone H3 lysine 27 (H3K27) is a posttranslational modification that is highly correlated with genomic silencing. Here we show that human UTX, a member of the Jumonji C family of proteins, is a di- and trimethyl H3K27 demethylase. UTX occupies the promoters of HOX gene clusters and regulates their transcriptional output by modulating the recruitment of polycomb repressive complex 1 and the monoubiquitination of histone H2A. Moreover, UTX associates with mixed-lineage leukemia (MLL) 2/3 complexes, and during retinoic acid signaling events, the recruitment of the UTX complex to HOX genes results in H3K27 demethylation and a concomitant methylation of H3K4. Our results suggest a concerted mechanism for transcriptional activation in which cycles of H3K4 methylation by MLL2/3 are linked with the demethylation of H3K27 through UTX."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1149042"xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1149042"xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Lee M.G."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Lee M.G."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Villa R."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Villa R."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Norman J."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Norman J."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Shiekhattar R."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Shiekhattar R."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Trojer P."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Trojer P."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Di Croce L."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Di Croce L."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Yan K.P."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/author | "Yan K.P."xsd:string |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17761849 | http://purl.uniprot.org/core/name | "Science"xsd:string |