| http://purl.uniprot.org/citations/17761850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17761850 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) repress hundreds of target messenger RNAs (mRNAs), but the physiological roles of specific miRNA-mRNA interactions remain largely elusive. We report that zebrafish microRNA-430 (miR-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta Nodal antagonist lefty. To disrupt the interaction of specific miRNA-mRNA pairs, we developed target protector morpholinos complementary to miRNA binding sites in target mRNAs. Protection of squint or lefty mRNAs from miR-430 resulted in enhanced or reduced Nodal signaling, respectively. Simultaneous protection of squint and lefty or absence of miR-430 caused an imbalance and reduction in Nodal signaling. These findings establish an approach to analyze the in vivo roles of specific miRNA-mRNA pairs and reveal a requirement for miRNAs in dampening and balancing agonist/antagonist pairs."xsd:string |
| http://purl.uniprot.org/citations/17761850 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1147535"xsd:string |
| http://purl.uniprot.org/citations/17761850 | http://purl.uniprot.org/core/author | "Schier A.F."xsd:string |
| http://purl.uniprot.org/citations/17761850 | http://purl.uniprot.org/core/author | "Giraldez A.J."xsd:string |
| http://purl.uniprot.org/citations/17761850 | http://purl.uniprot.org/core/author | "Choi W.Y."xsd:string |
| http://purl.uniprot.org/citations/17761850 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17761850 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/17761850 | http://purl.uniprot.org/core/pages | "271-274"xsd:string |
| http://purl.uniprot.org/citations/17761850 | http://purl.uniprot.org/core/title | "Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430."xsd:string |
| http://purl.uniprot.org/citations/17761850 | http://purl.uniprot.org/core/volume | "318"xsd:string |
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| http://purl.uniprot.org/uniprot/#_O13144-mappedCitation-17761850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17761850 |
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| http://purl.uniprot.org/uniprot/O13144 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17761850 |