| http://purl.uniprot.org/citations/17761941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17761941 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveProliferation and migration of vascular smooth muscle cells (VSMCs) are striking features shared by vascular ageing, atherosclerosis, and in-stent restenosis. VSMC biology depends in part on polyamines whose metabolism is closely regulated by ornithine decarboxylase antizyme 1 (OAZ1). Therefore, we sought for association between OAZ1 gene polymorphisms and various outcomes involving VSMC proliferation.Methods and resultsSystematic screening of the OAZ1 gene enabled to detect 21 variants. The impact of 4 selected tag polymorphisms (+849C/T, +851G/T, +1804G/A, and +2222A/G) was evaluated in 3 independent association studies. In a sample of 205 patients, the +2222G allele was associated with an increased risk of 6-month coronary in-stent restenosis (OR [95%CI]=2.1 [1.2 to 3.6]; P=0.0071). In a sample of 1001 subjects participating to the EVA study, the +2222G allele was longitudinally associated with a 4-year increase in common carotid intima-media thickness (P=0.047). In a case-control study (466 cases versus 466 controls), the risk of coronary heart disease associated with the +2222G allele was 1.3 (95%CI=[1.1 to 1.6]; P=0.026). No other significant association was consistently detected.ConclusionsWe identified the OAZ1+2222A/G polymorphism as a potential genetic marker of vascular events. Our findings strengthen the hypothesis that the polyamine metabolism plays a role in vascular diseases."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.org/dc/terms/identifier | "doi:10.1161/atvbaha.107.150458"xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Hamon M."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Amouyel P."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Dumont J."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Brousseau T."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Bauters C."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Cottel D."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Ducimetiere P."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Montaye M."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Zureik M."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/author | "Grupposo M.C."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/name | "Arterioscler Thromb Vasc Biol"xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/pages | "2120-2126"xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/title | "Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events."xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17761941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17761941 |
| http://purl.uniprot.org/citations/17761941 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17761941 |
| http://purl.uniprot.org/uniprot/#_J3QQY4-mappedCitation-17761941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17761941 |
| http://purl.uniprot.org/uniprot/#_Q2M222-mappedCitation-17761941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17761941 |
| http://purl.uniprot.org/uniprot/#_P54368-mappedCitation-17761941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17761941 |
| http://purl.uniprot.org/uniprot/P54368 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17761941 |
| http://purl.uniprot.org/uniprot/Q2M222 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17761941 |