| http://purl.uniprot.org/citations/17765678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17765678 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial tubes represent fundamental building blocks of metazoan organisms; however, the mechanisms responsible for their formation and maintenance are not well understood. Here, we show that the evolutionarily conserved coiled-coil MAGUK protein Dlg5 is required for epithelial tube maintenance in mammalian brain and kidneys. We demonstrate that Dlg5(-/-) mice develop fully penetrant hydrocephalus and kidney cysts caused by a deficiency in membrane delivery of cadherin-catenin adhesion complexes and loss of cell polarity. Dlg5 travels with cadherin-containing vesicles and binds to syntaxin 4, a t-SNARE protein that regulates fusion of transport vesicles with the lateral membrane domain. We propose that Dlg5 functions in plasma membrane delivery of cadherins by linking cadherin-containing transport vesicles with the t-SNARE targeting complex. These findings show that Dlg5 is causally involved in hydrocephalus and renal cysts and reveal that targeted membrane delivery of cadherin-catenin adhesion complexes is critical for cell polarity and epithelial tube maintenance."xsd:string |
| http://purl.uniprot.org/citations/17765678 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.07.017"xsd:string |
| http://purl.uniprot.org/citations/17765678 | http://purl.uniprot.org/core/author | "Nechiporuk T."xsd:string |
| http://purl.uniprot.org/citations/17765678 | http://purl.uniprot.org/core/author | "Vasioukhin V."xsd:string |
| http://purl.uniprot.org/citations/17765678 | http://purl.uniprot.org/core/author | "Fernandez T.E."xsd:string |
| http://purl.uniprot.org/citations/17765678 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17765678 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/17765678 | http://purl.uniprot.org/core/pages | "338-350"xsd:string |
| http://purl.uniprot.org/citations/17765678 | http://purl.uniprot.org/core/title | "Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice."xsd:string |
| http://purl.uniprot.org/citations/17765678 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-17765678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17765678 |