| http://purl.uniprot.org/citations/17766440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17766440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17766440 | http://www.w3.org/2000/01/rdf-schema#comment | "Iron-sulfur (Fe-S) proteins are key players in vital processes involving energy homeostasis and metabolism from the simplest to most complex organisms. We report a 1.5 A x-ray crystal structure of the first identified outer mitochondrial membrane Fe-S protein, mitoNEET. Two protomers intertwine to form a unique dimeric structure that constitutes a new fold to not only the approximately 650 reported Fe-S protein structures but also to all known proteins. We name this motif the NEET fold. The protomers form a two-domain structure: a beta-cap domain and a cluster-binding domain that coordinates two acid-labile 2Fe-2S clusters. Binding of pioglitazone, an insulin-sensitizing thiazolidinedione used in the treatment of type 2 diabetes, stabilizes the protein against 2Fe-2S cluster release. The biophysical properties of mitoNEET suggest that it may participate in a redox-sensitive signaling and/or in Fe-S cluster transfer."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0707189104"xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0707189104"xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Axelrod H.L."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Axelrod H.L."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Dixon J.E."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Dixon J.E."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Wiley S.E."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Wiley S.E."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Roy M."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Roy M."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Jennings P.A."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Jennings P.A."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Nechushtai R."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Nechushtai R."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Paddock M.L."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Paddock M.L."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Abresch E.C."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Abresch E.C."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Capraro D."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Capraro D."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Cohen A.E."xsd:string |
| http://purl.uniprot.org/citations/17766440 | http://purl.uniprot.org/core/author | "Cohen A.E."xsd:string |