| http://purl.uniprot.org/citations/17768347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17768347 | http://www.w3.org/2000/01/rdf-schema#comment | "Melanocytes are specialized pigmented cells that are found in all healthy skin tissue. In certain individuals, diseased melanocytes can form malignant tumours, melanomas, which cause the majority of skin-cancer-related deaths. The melanoma-associated antigenic peptides are presented on cell surfaces via the class I major histocompatibility complex (MHC). Among the melanoma-associated antigens, the melanoma self-antigen A/melanoma antigen recognized by T cells (Melan-A/MART-1) has attracted attention because of its wide expression in primary and metastatic melanomas. Here, a preliminary X-ray crystal structural study of a soluble cognate T-cell receptor (TCR) in complex with a pMHC presenting the Melan-A peptide (ELAGIGILTV) is reported. The TCR and pMHC were refolded, purified and mixed together to form complexes, which were crystallized using the sitting-drop vapour-diffusion method. Single TCR-pMHC complex crystals were cryocooled and used for data collection. Diffraction data showed that these crystals belonged to space group P4(1)/P4(3), with unit-cell parameters a = b = 120.4, c = 81.6 A. A complete data set was collected to 3.1 A and the structure is currently being analysed."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.org/dc/terms/identifier | "doi:10.1107/s1744309107037244"xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Gao G.F."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Yuan F."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Bell J.I."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Rizkallah P.J."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Sewell A.K."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Price D.A."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Georgiou T."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Jakobsen B.K."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Vuidepot A."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Sami M."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Moysey R."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Gostick E."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Gavarret J."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/author | "Hillon T."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/name | "Acta Crystallogr Sect F Struct Biol Cryst Commun"xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/pages | "758-760"xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/title | "Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex."xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/17768347 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17768347 |
| http://purl.uniprot.org/citations/17768347 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17768347 |
| http://purl.uniprot.org/uniprot/#_A0A384MR46-mappedCitation-17768347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17768347 |