| http://purl.uniprot.org/citations/17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17785790 | http://www.w3.org/2000/01/rdf-schema#comment | "The hemopoietic specific adapter protein ADAP (adhesion and degranulation-promoting adapter protein) positively regulates TCR-dependent, integrin-mediated adhesion and participates in signaling pathways downstream of the TCR that result in T cell activation. The specific role of ADAP in regulating Ag-dependent T cell interactions with APCs and T cell activation following Ag stimulation is not known. We used ADAP-/-DO11.10 T cells to demonstrate that ADAP promotes T cell conjugation to Ag-laden APCs. Complementary in vitro and in vivo approaches reveal that ADAP controls optimal T cell proliferation, cytokine production, and expression of the prosurvival protein Bcl-xL in response to limiting Ag doses. Furthermore, ADAP is critical for clonal expansion in vivo independent of Ag concentration under conditions of low clonal abundance. These results suggest that ADAP regulates T cell activation by promoting Ag-dependent T cell-APC interactions, resulting in enhanced T cell sensitivity to Ag, and by participating in prosurvival signaling pathways initiated by Ag stimulation."xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.6.3559"xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/author | "Shimizu Y."xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/author | "Thomas M.S."xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/author | "Mueller K.L."xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/author | "Peterson E.J."xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/author | "Burbach B.J."xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/pages | "3559-3569"xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/title | "Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival."xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/17785790 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17785790 |
| http://purl.uniprot.org/citations/17785790 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17785790 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPY6-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRH1-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |
| http://purl.uniprot.org/uniprot/#_B2RUR0-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |
| http://purl.uniprot.org/uniprot/#_O15117-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |
| http://purl.uniprot.org/uniprot/#_O35601-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |
| http://purl.uniprot.org/uniprot/#_F6V072-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |
| http://purl.uniprot.org/uniprot/#_Q8CAX4-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |
| http://purl.uniprot.org/uniprot/#_Q05DE9-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |
| http://purl.uniprot.org/uniprot/#_Q3TA12-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |
| http://purl.uniprot.org/uniprot/#_Q9P1I1-mappedCitation-17785790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785790 |