| http://purl.uniprot.org/citations/17785822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17785822 | http://www.w3.org/2000/01/rdf-schema#comment | "We have recently shown that Zap70 is important in retinoid receptor-dependent transactivation in T lymphocytes. We report that Zap70 signaling is also essential in dexamethasone-inducible glucocorticoid receptor (GR)-mediated transactivation in T lymphocytes. Zap70-negative Jurkat T cells and cells reconstituted with inactive Zap70 exhibited attenuated GR-mediated activation as compared with Zap70 reconstituted and wild-type cells. Lck-lacking Jurkat cells were also found to show markedly reduced GR activation, and reconstitution with Lck restored the activation. Gene array and protein analysis showed that the level of annexin 1 (ANXA1), an anti-inflammatory protein known to be induced and released by the glucocorticoid action, was significantly reduced in Zap70-negative and Zap70-inactive Jurkat cells as compared with wild-type cells. Lck-lacking cells were also found to have markedly reduced ANXA1 levels and reconstitution with Lck restored the ANXA1 expression. RNA interference-induced knockdown of Zap70 or Lck in Jurkat cells and peripheral blood T lymphocytes also resulted in the loss of ANXA1 expression. Transcriptional analysis revealed that dexamethasone-inducible GR-mediated activation of ANXA1 promoter was compromised in both Zap70 knocked down peripheral blood T cells and Zap70 or Lck-deficient/Lck-inactive Jurkat cells, indicating an essential role of these kinases in GR-mediated ANXA1 promoter activation in T lymphocytes. To summarize, our data demonstrate an important role for Zap70 signaling in GR-mediated transactivation in T lymphocytes and also point out a crucial role of this kinase in maintaining normal ANXA1 levels in these cells."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.6.3851"xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/author | "Hazen A."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/author | "Natarajan V."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/author | "Lempicki R.A."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/author | "Ishaq M."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/author | "DeGray G."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/author | "Mou K."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/pages | "3851-3858"xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/title | "Zap70 signaling pathway mediates glucocorticoid receptor-dependent transcriptional activation: role in the regulation of annexin 1 expression in T cells."xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/17785822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17785822 |
| http://purl.uniprot.org/citations/17785822 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17785822 |
| http://purl.uniprot.org/uniprot/#_B4E0E2-mappedCitation-17785822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785822 |
| http://purl.uniprot.org/uniprot/#_P43403-mappedCitation-17785822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17785822 |
| http://purl.uniprot.org/uniprot/P43403 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17785822 |
| http://purl.uniprot.org/uniprot/B4E0E2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17785822 |