| http://purl.uniprot.org/citations/17785848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17785848 | http://www.w3.org/2000/01/rdf-schema#comment | "B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory receptor that is predominantly expressed on T and B cells and dampens T cell activation. In this study, we analyzed the function of BTLA during infection with Plasmodium berghei ANKA. Infection of C57BL/6 mice with this strain leads to sequestration of leukocytes in brain capillaries that is associated with a pathology resembling cerebral malaria in humans. During the course of infection, we found an induction of BTLA in several organs, which was either due to up-regulation of BTLA expression on T cells in the spleen or due to infiltration of BTLA-expressing T cells into the brain. In the brain, we observed a marked induction of BTLA and its ligand herpesvirus entry mediator during cerebral malaria, which was accompanied by an accumulation of predominantly CD8+ T cells, but also CD4+ T cells. Application of an agonistic anti-BTLA mAb caused a significantly reduced incidence of cerebral malaria compared with control mice. Treatment with this Ab also led to a decreased number of T cells that were sequestered in the brain of P. berghei ANKA-infected mice. Our findings indicate that BTLA-herpesvirus entry mediator interactions are functionally involved in T cell regulation during P. berghei ANKA infection of mice and that BTLA is a potential target for therapeutic interventions in severe malaria."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.6.4093"xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/author | "Jacobs T."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/author | "Pfeffer K."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/author | "Fleischer B."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/author | "Murphy T.L."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/author | "Hurchla M.A."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/author | "Lepenies B."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/author | "Oetzel J."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/pages | "4093-4100"xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/title | "Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral malaria."xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/17785848 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17785848 |
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