| http://purl.uniprot.org/citations/17786318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17786318 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a 465-kDa catalytic subunit of DNA-PK, a DNA repair apparatus. DNA-PKcs has been reported to be a tumor suppressor, but details of its expression in human cancer are controversial. To determine the protein expression and clinical implications of DNA-PKcs in gastric carcinogenesis and cancer progression, we evaluated its expression status by immunohistochemistry in 122 non-neoplastic gastric mucosa samples, and in 115 gastric adenomas and 564 consecutive gastric cancers. In addition, we evaluated the clinicopathologic characteristics of gastric cancers showing altered DNA-PKcs expression, and performed microsatellite instability (MSI) analysis at BAT-26 and frameshift mutation analysis of DNA-PKcs. DNA-PKcs expression was negative in foveolar epithelium of normal gastric mucosal tissues, but was positive in most Helicobacter pylori-associated gastritis, intestinal metaplasia and gastric adenoma tissues. In gastric cancers, negative expression of DNA-PKcs was found in 114 of the 564 (20.2%) cancers and was significantly associated with intratumoral neutrophils, MSI-high (H) phenotype, tumor progression, and poor patient survival (p<0.05). Frameshift mutations of (A)10 mononucleotide repeats in DNA-PKcs were found in 24.3% of MSI-H gastric cancers and these were associated with negative expression of DNA-PKcs. Although patients with MSI-H gastric cancers were found to have a lower risk of lymph node metastasis, gastric cancers harboring the (A)10 mutation of DNA-PKcs were found to have a higher risk of lymph node metastasis. In conclusion, the expression of DNA-PKcs was found to be altered during gastric carcinogenesis and negative DNA-PKcs expression was associated with gastric cancer progression. The (A)10 frameshift mutation of DNA-PKcs in gastric cancers was a target of defective mismatch repair, and was associated with lymph node metastasis."xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/author | "Lee H.S."xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/author | "Park D.J."xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/author | "Lee B.L."xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/author | "Kim W.H."xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/author | "Yang H.K."xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/author | "Park K.U."xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/author | "Choe G."xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/name | "Int J Oncol"xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/pages | "859-866"xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/title | "Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/17786318 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17786318 |
| http://purl.uniprot.org/citations/17786318 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17786318 |
| http://purl.uniprot.org/uniprot/#_B4DL41-mappedCitation-17786318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17786318 |
| http://purl.uniprot.org/uniprot/#_P78527-mappedCitation-17786318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17786318 |
| http://purl.uniprot.org/uniprot/P78527 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17786318 |
| http://purl.uniprot.org/uniprot/B4DL41 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17786318 |