| http://purl.uniprot.org/citations/17823124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17823124 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I interferon gene induction relies on IKK-related kinase TBK1 and IKKepsilon-mediated phosphorylations of IRF3/7 through the Toll-like receptor-dependent signaling pathways. The scaffold proteins that assemble these kinase complexes are poorly characterized. We show here that TANK/ITRAF is required for the TBK1- and IKKepsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-dependent pathways and is part of a TRAF3-containing complex. Moreover, TANK is dispensable for the early phase of double-stranded RNA-mediated IRF3 phosphorylation. Interestingly, TANK is heavily phosphorylated by TBK1-IKKepsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKepsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKKepsilon kinase activity. Thus, we have identified TANK as a scaffold protein that assembles some but not all IRF3/7-phosphorylating TBK1-IKKepsilon complexes and demonstrated that these kinases possess two functions, namely the phosphorylation of both IRF3/7 and TANK as well as the recruitment of an E3 ligase for Lys(63)-linked polyubiquitination of their scaffold protein, TANK."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701690200"xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Brown K."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Piette J."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Siebenlist U."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Dejardin E."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Chariot A."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Warnier M."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Close P."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Chapelle J.P."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Muraille E."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Gioia R."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Gatot J.S."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Chau T.L."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/author | "Patrascu F."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/pages | "31131-31146"xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/title | "Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF."xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17823124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17823124 |
| http://purl.uniprot.org/citations/17823124 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17823124 |
| http://purl.uniprot.org/uniprot/#_B2R7S3-mappedCitation-17823124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17823124 |
| http://purl.uniprot.org/uniprot/#_B4E164-mappedCitation-17823124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17823124 |