| http://purl.uniprot.org/citations/17826745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17826745 | http://www.w3.org/2000/01/rdf-schema#comment | "PWS is caused by the loss of expression of a set of maternally imprinted genes including NECDIN (NDN). NDN is expressed in post-mitotic neurons and plays an essential role in PWS as mouse models lacking only the Ndn gene mimic aspects of this disease. Patients haploid for SIM1 develop a PW-like syndrome. Here, we report that NDN directly interacts with ARNT2, a bHLH-PAS protein and dimer partner for SIM1. We also found that NDN can interact with HIF1alpha. We showed that NDN can repress transcriptional activation mediated by ARNT2:SIM1 as well as ARNT2:HIF1alpha. The N-terminal 115 residues of NDN are sufficient for interaction with the bHLH domains of ARNT2 or HIF1alpha but not for transcriptional repression. Using GAL4-NDN fusion proteins, we determined that NDN possesses multiple repression domains. We thus propose that NDN regulates neuronal function and hypoxic response by regulating the activities of the ARNT2:SIM1 and ARNT2:HIF1alpha dimers, respectively."xsd:string |
| http://purl.uniprot.org/citations/17826745 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.08.108"xsd:string |
| http://purl.uniprot.org/citations/17826745 | http://purl.uniprot.org/core/author | "Fan C.M."xsd:string |
| http://purl.uniprot.org/citations/17826745 | http://purl.uniprot.org/core/author | "Friedman E.R."xsd:string |
| http://purl.uniprot.org/citations/17826745 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17826745 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17826745 | http://purl.uniprot.org/core/pages | "113-118"xsd:string |
| http://purl.uniprot.org/citations/17826745 | http://purl.uniprot.org/core/title | "Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription."xsd:string |
| http://purl.uniprot.org/citations/17826745 | http://purl.uniprot.org/core/volume | "363"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-17826745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17826745 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-17826745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17826745 |
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| http://purl.uniprot.org/uniprot/#_A0A140LHY4-mappedCitation-17826745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17826745 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2YDK5-mappedCitation-17826745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17826745 |
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| http://purl.uniprot.org/uniprot/#_A0A140LID9-mappedCitation-17826745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17826745 |
| http://purl.uniprot.org/uniprot/#_A0A140LIL3-mappedCitation-17826745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17826745 |
| http://purl.uniprot.org/uniprot/#_A0A140LIW9-mappedCitation-17826745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17826745 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7V8-mappedCitation-17826745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17826745 |