| http://purl.uniprot.org/citations/17828269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17828269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17828269 | http://www.w3.org/2000/01/rdf-schema#comment | "Antigen-specific B cells are selected in germinal centers, the structure in which these cells proliferate while accomplishing genome-remodeling processes such as class-switch recombination and somatic hypermutation. These events are associated with considerable genotoxic stress, which cells tolerate through suppression of DNA-damage responses by Bcl-6, a transcription factor required for the formation of germinal centers. Here we show that the expression of Bcl-6 is regulated by DNA damage through a signaling pathway that promotes Bcl-6 degradation. After DNA damage accumulated, the kinase ATM promoted Bcl-6 phosphorylation, leading to its interaction with the isomerase Pin1 and its degradation by the ubiquitin-proteasome system. Because Bcl-6 is required for the maintenance of germinal centers, our findings suggest that the extent of genotoxic stress controls the fate of germinal center B cells by means of Bcl-6."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1508"xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1508"xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Saito M."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Saito M."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Kitagawa Y."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Kitagawa Y."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Means A.R."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Means A.R."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Dalla-Favera R."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Dalla-Favera R."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Phan R.T."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/author | "Phan R.T."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/pages | "1132-1139"xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/pages | "1132-1139"xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/title | "Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/title | "Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells."xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/17828269 | http://purl.uniprot.org/core/volume | "8"xsd:string |