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http://purl.uniprot.org/citations/17845537http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17845537http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

C-reactive protein (CRP) was recently identified as a prognostic factor for patients with hepatocellular carcinoma (HCC) after surgical resection. We investigated the relationship between the serum levels of high sensitivity CRP (H-CRP) and the prognosis of HCC patients.

Method

We conducted a cohort study of 90 HCC patients enrolled from 1997 to 1998. All patients were treated and followed for a mean period of 3.2 years. Clinical variables were compared between patients positive for H-CRP (serum H-CRP levels >/=3.0 mg/L, n=47) and those negative for H-CRP (serum H-CRP levels <3.0 mg/L, n=43). We also determined the relationship between serum H-CRP and prognosis in HCC patients.

Results

The survival rate of patients of the H-CRP-positive group was lower than that of H-CRP-negative patients. Tumour stage (stages 3 or 4), total bilirubin >/=1.2 mg/dL, albumin (Alb) <3.5 g/dL, des-gamma-carboxy prothrombin >/=40 mAU/mL, positive H-CRP and initial treatment (transcatheter arterial chemoembolization, hepatic arterial infusion chemotherapy or best supportive care) were identified as significant poor prognostic factors by univariate analysis, while positive H-CRP [hazard ratio (HR), 1.58; P=0.048], Alb<3.5 g/dL (HR, 2.10; P=0.004), tumour stage (stages 3 or 4; HR, 3.05; P=0.001) and initial treatment (HR, 1.88; P=0.029) were considered to be significant determinants of poor prognosis by multivariate Cox proportional hazards analysis.

Conclusions

The prognosis of H-CRP-positive patients was poorer compared with H-CRP-negative patients. This study confirmed that H-CRP, like CRP, is a marker of poor prognosis in HCC patients."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.org/dc/terms/identifier"doi:10.1111/j.1478-3231.2007.01550.x"xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Inoue K."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Koga H."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Nagaoka S."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Yoshida T."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Adachi H."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Imaizumi T."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Sata M."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Akiba J."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Kojiro M."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Akiyoshi J."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Torimura T."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Niizeki T."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Kurogi J."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/author"Tajiri N."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/name"Liver Int"xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/pages"1091-1097"xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/title"Serum C-reactive protein levels predict survival in hepatocellular carcinoma."xsd:string
http://purl.uniprot.org/citations/17845537http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/17845537http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17845537
http://purl.uniprot.org/citations/17845537http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17845537
http://purl.uniprot.org/uniprot/#_C9JRE9-mappedCitation-17845537http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17845537
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