| http://purl.uniprot.org/citations/17847023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17847023 | http://www.w3.org/2000/01/rdf-schema#comment | "K-ras and mucin profile variations, associated with intestinal carcinogenesis, were studied in the preneoplastic lesions, mucin-depleted foci (MDF) and aberrant crypt foci (ACF), and in colonic tumors induced in rats by 1,2-dimethylhydrazine (DMH). The frequency of lesions with K-ras mutations was 23% (3/13), 5.5% (1/18) and 100% (14/14) in MDF, tumors and ACF, respectively. Two of three MDF mutated in K-ras also carried a missense mutation in Apc. We also tested the expression of MUC2, a mucin abundantly expressed in normal colon and M1/MUCA5C, up-regulated in colon carcinogenesis, using immunohistochemistry. MDF and tumors showed a dramatic reduction in the expression of MUC2, whereas ACF showed only a slight reduction. The expression of M1/MUC5AC was almost absent in normal mucosa, but was increased in all the lesions (MDF, tumors and ACF). The expression of the intestinal trefoil factor (ITF), a marker of goblet cell lineage, was reduced in MDF and tumors compared to normal mucosa but not in ACF. In conclusion, although K-ras mutations are present in all ACF, they are less frequent in MDF and tumors; M1/MUC5AC is a marker associated with all preneoplastic events while the reduction of MUC2 and ITF expression is selectively associated with more advanced lesions such as MDF and tumors."xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.23065"xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/author | "Ferri S."xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/author | "Caderni G."xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/author | "Dolara P."xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/author | "Giannini A."xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/author | "Femia A.P."xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/author | "Salvadori M."xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/author | "Tarquini E."xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/pages | "117-123"xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/title | "K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine."xsd:string |
| http://purl.uniprot.org/citations/17847023 | http://purl.uniprot.org/core/volume | "122"xsd:string |
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