| http://purl.uniprot.org/citations/17849054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17849054 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptor-4 (TLR-4) gene polymorphisms have been associated with a lower risk of atherosclerosis. High levels of soluble P-selectin (sP-selectin) and von Willebrand factor predict an increased risk for cardiovascular events and correlate to atherosclerotic risk factors. The relationship between these markers and TLR-4 gene polymorphisms was evaluated in a cohort of consecutive hypercholesterolemic outpatients. TLR-4 gene polymorphisms were detected in 48 out of 330 (14%) patients with hypercholesterolemia. Lipid and inflammatory markers, sP-selectin and von Willebrand were evaluated in carriers and in 96 (ratio 2:1 to cases) age- and sex-matched TLR-4 wild-type patients randomly selected from the same population. A cohort of normocholesterolemic outpatients (n = 262) served as the control group. sP-selectin was sensibly lower in carriers of TLR-4 variants as compared to wild-types and controls (89 ng/ml vs. 162 ng/ml and 163 ng/dl, respectively, p = 0.0001). Similarly, carriers showed lower von Willebrand factor values (683 mU/ml) than wild-types (910 mU/ml; p = 0.001). In multivariate analysis, TLR-4 gene polymorphisms were positively associated with sP-selectin, whereas the relationship with von Willebrand factor was no longer significant. HMG-CoA reductase inhibitors reduced sP-selectin and von Willebrand factor levels independently of TLR-4 gene variants. Plasma concentrations of these markers, however, remained lower in carriers of TLR-4 gene polymorphisms even after cholesterol lowering. In conclusion, carriership of Asp299 and Thr399Ile TLR-4 gene polymorphisms is associated with lower levels of sP-selectin and von Willebrand factor among hypercholesterolemic patients. While the underlying mechanisms remain to be investigated, such an association may indicate a protective effect of TLR-4 variants for atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.org/dc/terms/identifier | "doi:10.1160/th07-02-0099"xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/author | "Stuppia L."xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/author | "Cuccurullo F."xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/author | "Di Febbo C."xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/author | "Di Nisio M."xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/author | "Porreca E."xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/author | "Moretta V."xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/author | "Guglielmi M.D."xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/name | "Thromb Haemost"xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/pages | "642-646"xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/title | "Effects of toll-like receptor-4 gene polymorphisms on soluble P-selectin and von Willebrand factor levels in hypercholesterolemic patients."xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/17849054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17849054 |
| http://purl.uniprot.org/citations/17849054 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17849054 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z509-mappedCitation-17849054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17849054 |
| http://purl.uniprot.org/uniprot/#_A0A858XAB0-mappedCitation-17849054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17849054 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4F5-mappedCitation-17849054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17849054 |
| http://purl.uniprot.org/uniprot/#_B2R785-mappedCitation-17849054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17849054 |
| http://purl.uniprot.org/uniprot/#_B4DVS9-mappedCitation-17849054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17849054 |
| http://purl.uniprot.org/uniprot/#_B4DMS3-mappedCitation-17849054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17849054 |
| http://purl.uniprot.org/uniprot/#_B4DNX0-mappedCitation-17849054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17849054 |
| http://purl.uniprot.org/uniprot/#_A8K7V7-mappedCitation-17849054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17849054 |