| http://purl.uniprot.org/citations/17855024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17855024 | http://www.w3.org/2000/01/rdf-schema#comment | "RIM-binding proteins (RIM-BPs) were identified as binding partners of the presynaptic active zone proteins RIMs as well as for voltage-gated Ca(2+)-channels. They were suggested to form a functional link between the synaptic-vesicle fusion apparatus and Ca(2+)-channels. Here we show that the RIM-BP gene family diversified in different stages during evolution, but retained their unique domain structure. While invertebrate genomes contain one, and vertebrates include at least two RIM-BPs, we identified an additional gene, RIM-BP3, which is exclusively expressed in mammals. RIM-BP3 is encoded by a single exon of which three copies are present in the human genome. All RIM-BP genes encode proteins with three SH3-domains and two to three fibronectin III repeats. The flanking regions diverge in size and sequence and are alternatively spliced in RIM-BP1 and -2. Quantitative real-time RT-PCR and in situ hybridization analyses revealed overlapping but distinct expression patterns throughout the brain for RIM-BP1 and -2, while RIM-BP3 was detected at high levels outside the nervous system. The modular domain structure of RIM-BPs, their expression pattern and the conservative expansion during evolution shown here support their potential role as important molecular adaptors."xsd:string |
| http://purl.uniprot.org/citations/17855024 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2007.08.004"xsd:string |
| http://purl.uniprot.org/citations/17855024 | http://purl.uniprot.org/core/author | "Schoch S."xsd:string |
| http://purl.uniprot.org/citations/17855024 | http://purl.uniprot.org/core/author | "Mittelstaedt T."xsd:string |
| http://purl.uniprot.org/citations/17855024 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17855024 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/17855024 | http://purl.uniprot.org/core/pages | "70-79"xsd:string |
| http://purl.uniprot.org/citations/17855024 | http://purl.uniprot.org/core/title | "Structure and evolution of RIM-BP genes: identification of a novel family member."xsd:string |
| http://purl.uniprot.org/citations/17855024 | http://purl.uniprot.org/core/volume | "403"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A2R8Y6Z0-mappedCitation-17855024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17855024 |
| http://purl.uniprot.org/uniprot/#_D3YXR8-mappedCitation-17855024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17855024 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JFB0-mappedCitation-17855024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17855024 |
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| http://purl.uniprot.org/uniprot/#_O15034-mappedCitation-17855024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17855024 |
| http://purl.uniprot.org/uniprot/#_O95153-mappedCitation-17855024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17855024 |
| http://purl.uniprot.org/uniprot/#_Q9JIR1-mappedCitation-17855024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17855024 |