| http://purl.uniprot.org/citations/17870073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17870073 | http://www.w3.org/2000/01/rdf-schema#comment | "The inhibition of hepatic glycogen-associated protein phosphatase-1 (PP1-G(L)) by glycogen phosphorylase a prevents the dephosphorylation and activation of glycogen synthase, suppressing glycogen synthesis when glycogenolysis is activated. Here, we show that a peptide ((280)LGPYY(284)) comprising the last five amino acids of G(L) retains high-affinity interaction with phosphorylase a and that the two tyrosines play crucial roles. Tyr284 deletion abolishes binding of phosphorylase a to G(L) and replacement by phenylalanine is insufficient to restore high-affinity binding. We show that a phosphorylase inhibitor blocks the interaction of phosphorylase a with the G(L) C-terminus, suggesting that the latter interaction could be targeted to develop an anti-diabetic drug."xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2007.08.073"xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/author | "Munro S."xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/author | "Hallyburton I."xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/author | "Kelsall I.R."xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/author | "Cohen P.T."xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/author | "Treadway J.L."xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/pages | "4749-4753"xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/title | "The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug."xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://purl.uniprot.org/core/volume | "581"xsd:string |
| http://purl.uniprot.org/citations/17870073 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17870073 |
| http://purl.uniprot.org/citations/17870073 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17870073 |
| http://purl.uniprot.org/uniprot/#_P00489-mappedCitation-17870073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17870073 |
| http://purl.uniprot.org/uniprot/#_Q00756-mappedCitation-17870073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17870073 |
| http://purl.uniprot.org/uniprot/P00489 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17870073 |
| http://purl.uniprot.org/uniprot/Q00756 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17870073 |