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http://purl.uniprot.org/citations/17870207 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the expression of the neurotensin high-affinity receptor 1 (NTS1) during inflammatory bowel disease (IBD)-related colorectal oncogenesis, in colonic samples from 30 patients with IBD-related adenocarcinomas, dysplasias, and inflammatory mucosa (IM). The percentage of NTS1-positive epithelial cells progressively increased from the inflammatory condition to adenocarcinoma and was significantly higher in adenocarcinomas than in IM (p=0.0169). In parallel, the percentage of neurotensin (NT)-positive epithelial cells increased during the IBD-related oncogenesis. Finally, as NTS1 is a ss-catenin inducible gene, we found that a number of preneoplastic lesions and adenocarcinomas co-expressed NTS1 and beta-catenin without NT expression. Therefore, this study suggests two pathways of NTS1 overexpression during IBD-related oncogenesis: one triggered by NT overexpression, and a second associated with an activation of the APC/beta-catenin pathway, these two pathways being not mutually exclusive."xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2007.06.030"xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/author | "Laboisse C.L."xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/author | "Bezieau S."xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/author | "Bossard C."xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/author | "Mosnier J.F."xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/author | "Forgez P."xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/author | "Jarry A."xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/author | "Souaze F."xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/pages | "2030-2035"xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/title | "Over-expression of neurotensin high-affinity receptor 1 (NTS1) in relation with its ligand neurotensin (NT) and nuclear beta-catenin in inflammatory bowel disease-related oncogenesis."xsd:string |
http://purl.uniprot.org/citations/17870207 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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