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http://purl.uniprot.org/citations/17870207http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17870207http://www.w3.org/2000/01/rdf-schema#comment"We investigated the expression of the neurotensin high-affinity receptor 1 (NTS1) during inflammatory bowel disease (IBD)-related colorectal oncogenesis, in colonic samples from 30 patients with IBD-related adenocarcinomas, dysplasias, and inflammatory mucosa (IM). The percentage of NTS1-positive epithelial cells progressively increased from the inflammatory condition to adenocarcinoma and was significantly higher in adenocarcinomas than in IM (p=0.0169). In parallel, the percentage of neurotensin (NT)-positive epithelial cells increased during the IBD-related oncogenesis. Finally, as NTS1 is a ss-catenin inducible gene, we found that a number of preneoplastic lesions and adenocarcinomas co-expressed NTS1 and beta-catenin without NT expression. Therefore, this study suggests two pathways of NTS1 overexpression during IBD-related oncogenesis: one triggered by NT overexpression, and a second associated with an activation of the APC/beta-catenin pathway, these two pathways being not mutually exclusive."xsd:string
http://purl.uniprot.org/citations/17870207http://purl.org/dc/terms/identifier"doi:10.1016/j.peptides.2007.06.030"xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/author"Laboisse C.L."xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/author"Bezieau S."xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/author"Bossard C."xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/author"Mosnier J.F."xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/author"Forgez P."xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/author"Jarry A."xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/author"Souaze F."xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/name"Peptides"xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/pages"2030-2035"xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/title"Over-expression of neurotensin high-affinity receptor 1 (NTS1) in relation with its ligand neurotensin (NT) and nuclear beta-catenin in inflammatory bowel disease-related oncogenesis."xsd:string
http://purl.uniprot.org/citations/17870207http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/17870207http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17870207
http://purl.uniprot.org/citations/17870207http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17870207
http://purl.uniprot.org/uniprot/#_G3V1X6-mappedCitation-17870207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17870207
http://purl.uniprot.org/uniprot/#_Q86U50-mappedCitation-17870207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17870207
http://purl.uniprot.org/uniprot/#_P30990-mappedCitation-17870207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17870207
http://purl.uniprot.org/uniprot/#_Q6FH20-mappedCitation-17870207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17870207
http://purl.uniprot.org/uniprot/P30990http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17870207
http://purl.uniprot.org/uniprot/Q6FH20http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17870207
http://purl.uniprot.org/uniprot/G3V1X6http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17870207
http://purl.uniprot.org/uniprot/Q86U50http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17870207