| http://purl.uniprot.org/citations/17872438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17872438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17872438 | http://www.w3.org/2000/01/rdf-schema#comment | "Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown. We report a dominant-negative TLR3 allele in otherwise healthy children with herpes simplex virus 1 (HSV-1) encephalitis. TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1139522"xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1139522"xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Zhang X.-X."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Zhang X.-X."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Romero P."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Romero P."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Hamilton C."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Hamilton C."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Leonard J."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Leonard J."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Zhang S.-Y."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Zhang S.-Y."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Smahi A."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Smahi A."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Abel L."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Abel L."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Geissmann F."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Geissmann F."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "von Bernuth H."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "von Bernuth H."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Segal D."xsd:string |
| http://purl.uniprot.org/citations/17872438 | http://purl.uniprot.org/core/author | "Segal D."xsd:string |