| http://purl.uniprot.org/citations/17873880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17873880 | http://www.w3.org/2000/01/rdf-schema#comment | "The cardioprotective effects of estrogen are mediated by receptors expressed in vascular cells. Here we show that 27-hydroxycholesterol (27HC), an abundant cholesterol metabolite that is elevated with hypercholesterolemia and found in atherosclerotic lesions, is a competitive antagonist of estrogen receptor action in the vasculature. 27HC inhibited both the transcription-mediated and the non-transcription-mediated estrogen-dependent production of nitric oxide by vascular cells, resulting in reduced estrogen-induced vasorelaxation of rat aorta. Furthermore, increasing 27HC levels in mice by diet-induced hypercholesterolemia, pharmacologic administration or genetic manipulation (by knocking out the gene encoding the catabolic enzyme CYP7B1) decreased estrogen-dependent expression of vascular nitric oxide synthase and repressed carotid artery reendothelialization. As well as antiestrogenic effects, there were proestrogenic actions of 27HC that were cell-type specific, indicating that 27HC functions as an endogenous selective estrogen receptor modulator (SERM). Taken together, these studies point to 27HC as a contributing factor in the loss of estrogen protection from vascular disease."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm1641"xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/author | "Domoto H."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/author | "Mangelsdorf D.J."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/author | "Korach K.S."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/author | "Javitt N.B."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/author | "Cummins C.L."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/author | "Umetani M."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/author | "Shaul P.W."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/author | "Yuhanna I.S."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/author | "Gormley A.K."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/pages | "1185-1192"xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/title | "27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen."xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/17873880 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17873880 |
| http://purl.uniprot.org/citations/17873880 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17873880 |
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| http://purl.uniprot.org/uniprot/#_A0A140LHY6-mappedCitation-17873880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17873880 |
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