| http://purl.uniprot.org/citations/17873897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17873897 | http://www.w3.org/2000/01/rdf-schema#comment | "L1 is a cell adhesion molecule expressed at the invasive front of colorectal tumors with an important role in metastasis. The aim of the present study was to determine L1 protein expression in a large cohort of colorectal cancer patients and its impact on early metastatic spread and survival. A total of 375 patients that underwent surgical treatment for colorectal cancer were chosen retrospectively. A tissue microarray was constructed of 576 tissue samples from these patients and analyzed by immunohistochemistry with a monoclonal antibody against human L1 (UJ127). Lymph node and bone marrow micrometastasis were assessed with monoclonal antibodies Ber-EP4 and pancytokeratin A45-B/B3, respectively. Associations between L1 expression and lymph node, bone marrow micrometastasis and survival were investigated with Fisher's, log-rank test and Cox multivariate analysis. All statistical tests were two-sided. L1 was detected in a subset of 48 (13%) of 375 patients examined. Analysis of L1 expression and survival revealed a significantly worse outcome for L1-positive patients by log-rank test (P<0.05). Multivariate Cox regression analysis showed the strongest independent prognostic impact of L1 expression (P<0.05). Fisher's test revealed a significant association of L1 expression and presence of disseminated tumor cells in lymph nodes and bone marrow (P<0.05). L1 is a powerful prognostic marker for patients that undergo complete surgical resection. It may have a role in early metastatic spread, as L1 is associated with micrometastases to both the lymph nodes and bone marrow. Thus, L1 should be explored further as a target for adjuvant therapy for micrometastatic disease."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.org/dc/terms/identifier | "doi:10.1038/modpathol.3800955"xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Schneider C."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Schachner M."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Sauter G."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Pantel K."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Izbicki J.R."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Kaifi J.T."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Wachowiak R."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Yekebas E.F."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Quaas A."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Reichelt U."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Schurr P.G."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/author | "Strate T."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/name | "Mod Pathol"xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/pages | "1183-1190"xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/title | "L1 is associated with micrometastatic spread and poor outcome in colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/17873897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17873897 |
| http://purl.uniprot.org/citations/17873897 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17873897 |
| http://purl.uniprot.org/uniprot/#_A8K139-mappedCitation-17873897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17873897 |
| http://purl.uniprot.org/uniprot/#_P32004-mappedCitation-17873897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17873897 |
| http://purl.uniprot.org/uniprot/#_Q7Z2F9-mappedCitation-17873897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17873897 |