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| http://purl.uniprot.org/citations/17880909 | http://www.w3.org/2000/01/rdf-schema#comment | "Halogenated and polycyclic aromatic hydrocarbons induce diverse biochemical responses through the transformation of a cytosolic aryl hydrocarbon receptor (AhR). In mouse hepatoma Hepa-1c1c7 cells, curcumin, a yellow pigment of Curcuma longa, did not inhibit the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced translocation of the AhR into the nucleus, but rather accelerated it. In the nucleus, curcumin inhibited the TCDD-induced heterodimerization of the AhR with an AhR nuclear translocator (Arnt), an essential partner for the transformation, and also dose-dependently inhibited the TCDD-evoked phosphorylation of both the AhR and Arnt. Moreover, curcumin significantly inhibited the TCDD-induced activation of protein kinase C (PKC), which is involved in the transformation, decreased the TCDD-induced DNA-binding activity of the AhR/Arnt heterodimer, and downregulated CYP1A1 expression. In a cell-free system, curcumin inhibited the binding of 3-methylcholanthrene, an AhR agonist, to the receptor. These results indicate that curcumin is able to bind to the AhR as a ligand, but suppresses its transformation by inhibiting the phosphorylation of AhR and Arnt, probably by PKC."xsd:string |
| http://purl.uniprot.org/citations/17880909 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2007.08.007"xsd:string |
| http://purl.uniprot.org/citations/17880909 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/17880909 | http://purl.uniprot.org/core/author | "Ashida H."xsd:string |
| http://purl.uniprot.org/citations/17880909 | http://purl.uniprot.org/core/author | "Nishiumi S."xsd:string |
| http://purl.uniprot.org/citations/17880909 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17880909 | http://purl.uniprot.org/core/name | "Arch Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/17880909 | http://purl.uniprot.org/core/pages | "267-273"xsd:string |
| http://purl.uniprot.org/citations/17880909 | http://purl.uniprot.org/core/title | "Curcumin suppresses the transformation of an aryl hydrocarbon receptor through its phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/17880909 | http://purl.uniprot.org/core/volume | "466"xsd:string |
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