| http://purl.uniprot.org/citations/17881510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17881510 | http://www.w3.org/2000/01/rdf-schema#comment | "The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcepsilonRI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2. Although mouse mast cells constitutively express ST2, the effects of IL-33 on mast cell function are poorly understood. We found that IL-33, but not IL-1beta or IL-18, induced IL-13 and IL-6 production by mouse bone marrow-derived, cultured mast cells (BMCMCs) independently of IgE. In BMCMCs incubated with the potently cytokinergic SPE-7 IgE without specific antigen, IL-33, IL-1beta, and IL-18 each promoted IL-13 and IL-6 production, but the effects of IL-33 were more potent than those of IL-1beta or IL-18. IL-33 promoted cytokine production via a MyD88-dependent but Toll/IL-1R domain-containing adaptor-inducing IFN-beta-independent pathway. By contrast, IL-33 neither induced nor enhanced mast cell degranulation. At 200 ng/ml, IL-33 prolonged mast cell survival in the absence of IgE and impaired survival in the presence of SPE-7 IgE, whereas at 100 ng/ml, IL-33 had no effect on mast cell survival in the absence of IgE and reduced mast cell survival in the presence of IgE. These observations suggest potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0407200"xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Ohno T."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Suto H."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Galli S.J."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Nakae S."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Ho L.H."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Kajiwara N."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Okayama Y."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Iikura M."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/author | "Oboki K."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/pages | "1481-1490"xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/title | "IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals."xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/17881510 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17881510 |
| http://purl.uniprot.org/citations/17881510 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17881510 |
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| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-17881510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17881510 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-17881510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17881510 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-17881510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17881510 |