| http://purl.uniprot.org/citations/17881906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17881906 | http://www.w3.org/2000/01/rdf-schema#comment | "Among the many processes regulating cell death, ceramide signaling is a vital component. We previously determined that acid ceramidase (AC) is upregulated in 60% of primary prostate cancer (PCa) tissues, suggesting that AC may play a role in tumor development. In order to determine the significance of AC elevation, stable clones of DU145 cells with AC overexpression (AC-EGFP) were generated. Compared to controls (EGFP), AC-EGFP cells exhibited enhanced cell proliferation and migration. Subcutaneous injection of AC-EGFP cells into Nu/Nu mice resulted in larger tumor volumes compared to EGFP controls. Moreover, using the MTS viability assay, AC-EGFP cells were more resistant to cell death induced by doxorubicin, cisplatin, etoposide, gemcitabine or C6-ceramide. Conversely, knock down of AC using siRNA, sensitized AC-EGFP cells to these drugs. In addition, mass spectroscopic analysis of sphingolipids indicated that long chain ceramide levels were decreased in AC-EGFP cells treated with either doxorubicin or etoposide. In conclusion, this study implicates AC as a critical regulator of PCa progression by affecting not only tumor cell proliferation and migration but also responses to drug therapy, suggesting AC as a potential therapeutic target in advanced PCa."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.org/dc/terms/identifier | "doi:10.4161/cbt.6.9.4623"xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Bielawska A."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Bielawski J."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Hannun Y.A."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Obeid L.M."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Norris J.S."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Anelli V."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Bai A."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Elojeimy S."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Keane T.E."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Mahdy A.E."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Meacham W.D."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Saad A.F."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/author | "Turner L.S."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/name | "Cancer Biol Ther"xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/pages | "1455-1460"xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/title | "The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy."xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/17881906 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17881906 |
| http://purl.uniprot.org/citations/17881906 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17881906 |