| http://purl.uniprot.org/citations/17882010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17882010 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveCathepsin K is a cysteine protease that plays an essential role in organic bone matrix degradation. The aim of our study was to seek correlation of serum cathepsin K levels and a change in bone mineral density (BMD) over a 3-year period in a population of healthy nonosteoporotic women. The secondary end points were the correlations of serum cathepsin K with cross-sectional BMD and with other serum bone turnover markers and age.DesignIn 43 healthy women aged 42 to 57 years, blood samples for determination of cathepsin K, osteocalcin, bone alkaline phosphatase, C-terminal cross-linking telopeptide of type I collagen, osteoprotegerin, and nuclear factor kappaB ligand were collected at the time of the first BMD measurement. BMD measurements were repeated after 3 years.ResultsWe found a moderate negative correlation of serum cathepsin K levels with change in femoral neck BMD, but none with change in spinal BMD. There were no significant correlations between cross-sectional BMD of the spine or femoral neck and serum levels of cathepsin K. Serum levels of cathepsin K were not significantly correlated with any bone turnover markers studied or with age.ConclusionsSerum cathepsin K does not seem to represent a surrogate for bone turnover markers used at present, but it might be useful as a predictor of cortical bone loss."xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.org/dc/terms/identifier | "doi:10.1097/gme.0b013e3181271873"xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/author | "Marc J."xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/author | "Prezelj J."xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/author | "Ostanek B."xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/author | "Hawa G."xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/author | "Kocjan T."xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/author | "Logar D.B."xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/name | "Menopause"xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/pages | "369-373"xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/title | "Cathepsin K predicts femoral neck bone mineral density change in nonosteoporotic peri- and early postmenopausal women."xsd:string |
| http://purl.uniprot.org/citations/17882010 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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