| http://purl.uniprot.org/citations/17885208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17885208 | http://www.w3.org/2000/01/rdf-schema#comment | "NFATc1 has been characterized as a master regulator of nuclear factor kappaB ligand-induced osteoclast differentiation. Herein, we demonstrate a novel role for NFATc1 as a positive regulator of nuclear factor kappaB ligand-mediated osteoclast fusion as well as other fusion-inducing factors such as TNF-alpha. Exogenous overexpression of a constitutively active form of NFATc1 in bone marrow-derived monocyte/macrophage cells (BMMs) induces formation of multinucleated osteoclasts as well as the expression of fusion-mediating molecules such as the d2 isoform of vacuolar ATPase V(o) domain (Atp6v0d2) and the dendritic cell-specific transmembrane protein (DC-STAMP). Moreover, inactivation of NFATc1 by cyclosporin A treatment attenuates expression of Atp6v0d2 and DC-STAMP and subsequent fusion process of osteoclasts. We show that NFATc1 binds to the promoter regions of Atp6v0d2 and DC-STAMP in osteoclasts and directly induces their expression. Furthermore, overexpression of Atp6v0d2 and DC-STAMP rescues cell-cell fusion of preosteoclasts despite reduced NFATc1 activity. Our data indicate for the first time that the NFATc1/Atp6v0d2 and DC-STAMP signaling axis plays a key role in the osteoclast multinucleation process, which is essential for efficient bone resorption."xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2007-0237"xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/author | "Kim N."xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/author | "Ha Kim J."xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/pages | "176-185"xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/title | "NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP)."xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/17885208 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17885208 |
| http://purl.uniprot.org/citations/17885208 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17885208 |
| http://purl.uniprot.org/uniprot/#_B5B2N2-mappedCitation-17885208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17885208 |
| http://purl.uniprot.org/uniprot/#_B5B2N4-mappedCitation-17885208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17885208 |
| http://purl.uniprot.org/uniprot/#_B5B2N5-mappedCitation-17885208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17885208 |
| http://purl.uniprot.org/uniprot/#_B5B2N7-mappedCitation-17885208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17885208 |
| http://purl.uniprot.org/uniprot/#_Q3UME0-mappedCitation-17885208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17885208 |
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| http://purl.uniprot.org/uniprot/#_Q80SY3-mappedCitation-17885208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17885208 |
| http://purl.uniprot.org/uniprot/#_Q6P7T9-mappedCitation-17885208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17885208 |
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| http://purl.uniprot.org/uniprot/#_Q9JHD3-mappedCitation-17885208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17885208 |