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| http://purl.uniprot.org/citations/17888912 | http://www.w3.org/2000/01/rdf-schema#comment | "Our previous study reveals that connexin (Cx) 43 is targeted by ACh to prevent lethal arrhythmia. Granulocyte colony-stimulating factor (G-CSF), used against ischemic heart failure, may be another candidate, however, with unknown mechanisms. Therefore, we investigated the cellular effects of G-CSF. G-CSF activated the Wnt and Jak2 signals in cardiomyocytes, and up-regulated Cx43 protein and phosphorylation levels. In addition, G-CSF enhanced the localization of Cx43, beta-catenin and cadherin on the plasma membrane. G-CSF inhibited the reduction of Cx43 by enhancing Cx43 anchoring and sustained the cell-cell communication during hypoxia. Consequently, G-CSF suppressed ventricular arrhythmia induced by myocardial infarction. As a result, G-CSF could be used as a therapeutic tool for arrhythmia."xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2007.09.007"xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/author | "Ando M."xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/author | "Kakinuma Y."xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/author | "Doi Y."xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/author | "Kuwabara M."xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/author | "Yamasaki F."xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/author | "Katare R.G."xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/pages | "4821-4830"xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/title | "Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of beta-catenin and cadherin."xsd:string |
| http://purl.uniprot.org/citations/17888912 | http://purl.uniprot.org/core/volume | "581"xsd:string |
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