| http://purl.uniprot.org/citations/17889508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17889508 | http://www.w3.org/2000/01/rdf-schema#comment | "Our previous work revealed that gastrin regulates chromogranin A (CgA) transcription through enhanced binding of Sp1, CREB and Egr-1 to a proximal gastrin-responsive promoter element (Gas-RE). Here, we provide a detailed characterization of the signalling pathways transmitting the effect of gastrin on the CgA promoter. Gastrin treatment of gastric AGS-B cells potently stimulated MEK-1 as well as MAP kinases ERK-1/-2, JNK and p38 in a time-dependent manner. Interruption of ERK-1/-2/MEK-1 pathways abolished the transactivating effect of gastrin, whereas blockade of JNK or p38 activity was without effect. Functional promoter analysis revealed that the minimal element CgA-85/-64 was sufficient and necessary to confer MEK-1/ERK responsiveness. Analysis of proximal signalling pathways showed that activation of the MEK-1/ERK-1/2 module by gastrin does not require Ras, PI3-kinase or intracellular calcium signals, but depends on activation of kinases of the PKC family. This report demonstrates that a pathway comprising PKCs>Raf-1>MEK-1>ERK-1/-2 mediates the effect of gastrin on the CgA promoter, and strongly suggests that enhanced phosphorylation of Sp1 and CREB is crucial for CgA transactivation through the G protein-coupled CCK-B/gastrin receptor."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2007.08.016"xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/author | "Seufferlein T."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/author | "Wang T.C."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/author | "Cramer T."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/author | "Hocker M."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/author | "Juttner S."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/author | "Mergler S."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/author | "Plath T."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/author | "Merchant J."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/pages | "60-72"xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/title | "Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB."xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/17889508 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17889508 |
| http://purl.uniprot.org/citations/17889508 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17889508 |
| http://purl.uniprot.org/uniprot/#_E9PIC8-mappedCitation-17889508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17889508 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4L5-mappedCitation-17889508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17889508 |
| http://purl.uniprot.org/uniprot/#_A0A1S5UZ27-mappedCitation-17889508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17889508 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z559-mappedCitation-17889508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17889508 |
| http://purl.uniprot.org/uniprot/#_A0SEH4-mappedCitation-17889508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17889508 |
| http://purl.uniprot.org/uniprot/#_A0SEH5-mappedCitation-17889508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17889508 |
| http://purl.uniprot.org/uniprot/#_A0SEH6-mappedCitation-17889508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17889508 |