| http://purl.uniprot.org/citations/17889653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17889653 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular serpins such as antithrombin and alpha1-antitrypsin are the quintessential regulators of proteolytic pathways. In contrast, the biological functions of the intracellular serpins remain obscure. We now report that the C. elegans intracellular serpin, SRP-6, exhibits a prosurvival function by blocking necrosis. Minutes after hypotonic shock, srp-6 null animals underwent a catastrophic series of events culminating in lysosomal disruption, cytoplasmic proteolysis, and death. This newly defined hypo-osmotic stress lethal (Osl) phenotype was dependent upon calpains and lysosomal cysteine peptidases, two in vitro targets of SRP-6. By protecting against both the induction of and the lethal effects from lysosomal injury, SRP-6 also blocked death induced by heat shock, oxidative stress, hypoxia, and cation channel hyperactivity. These findings suggest that multiple noxious stimuli converge upon a peptidase-driven, core stress response pathway that, in the absence of serpin regulation, triggers a lysosomal-dependent necrotic cell death routine."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.07.013"xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Bromme D."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Watkins S.C."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Stolz D.B."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Long O.S."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Luke C.J."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Pak S.C."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Silverman G.A."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Barstead R.J."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Askew D.J."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Askew Y.S."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Moulder G.L."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Nobar S.M."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Naviglia T.L."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/author | "Vetica A.C."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/pages | "1108-1119"xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/title | "An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury."xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/17889653 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17889653 |
| http://purl.uniprot.org/citations/17889653 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17889653 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A3B4-mappedCitation-17889653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17889653 |