| http://purl.uniprot.org/citations/17890222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17890222 | http://www.w3.org/2000/01/rdf-schema#comment | "Cl(-) influx across the basolateral membrane is a limiting step in fluid production in exocrine cells and often involves functionally linked Cl(-)/HCO(3)(-) (Ae) and Na(+)/H(+) (Nhe) exchange mechanisms. The dependence of this major Cl(-) uptake pathway on Na(+)/H(+) exchanger expression was examined in the parotid acinar cells of Nhe1(-/-) and Nhe2(-/-) mice, both of which exhibited impaired fluid secretion. No change in Cl(-)/HCO(3)(-) exchanger activity was detected in Nhe2-deficient mice. Conversely, Cl(-)/HCO(3)(-) exchanger activity increased nearly 4-fold in Nhe1-deficient mice, despite only minimal or any change in mRNA and protein levels of the anion exchanger Ae2. Acetazolamide completely blocked the increase in Cl(-)/HCO(3)(-) exchanger activity in Nhe1-null mice suggesting that increased anion exchange required carbonic anhydrase activity. Indeed, the parotid glands of Nhe1(-/-) mice expressed higher levels of carbonic anhydrase 2 (Car2) polypeptide. Moreover, the enhanced Cl(-)/HCO(3)(-) exchange activity was accompanied by an increased abundance of Car2.Ae2 complexes in the parotid plasma membranes of Nhe1(-/-) mice. Anion exchanger activity was also significantly reduced in Car2-deficient mice, consistent with an important role of a putative Car2.Ae2 HCO(3)(-) transport metabolon in parotid exocrine cell function. Increased abundance of this HCO(3)(-) transport metabolon is likely one of the multiple compensatory changes in the exocrine parotid gland of Nhe1(-/-) mice that together attenuate the severity of in vivo electrolyte and acid-base balance perturbations."xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m707266200"xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/author | "Nakamoto T."xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/author | "Stewart A.K."xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/author | "Alper S.L."xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/author | "Nguyen H.V."xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/author | "Melvin J.E."xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/author | "Gonzalez-Begne M."xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/pages | "35125-35132"xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/title | "Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice."xsd:string |
| http://purl.uniprot.org/citations/17890222 | http://purl.uniprot.org/core/volume | "282"xsd:string |
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