Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/17890463http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17890463http://www.w3.org/2000/01/rdf-schema#comment"

Background

COPD is characterized by a persistent airflow limitation that is not fully reversible; thus, the reversibility of airflow limitations in response to a bronchodilator is an important component of COPD. Several studies have established that two common nonsynonymous polymorphisms in the beta2-adrenergic receptor gene (ADRB2), Arg16Gly and Gln27Glu, have important effects in modulating responses to beta2-agonists; however, the effects of these polymorphisms on responses to beta2-agonists in patients with COPD is unknown.

Objective

To examine whether different genotypes at these two polymorphisms are related to differential responses to inhaled beta2-agonists in patients with COPD.

Design and participants

A total of 246 patients with COPD who were participants in a longitudinal study of COPD (ie, the Hokkaido COPD cohort study) were studied. We compared short-term bronchodilator responses (BDRs) to salbutamol according to ADRB2 genotypes at codons 16 and 27.

Results

The presence of the Arg16 allele was associated with lower BDRs to beta2-agonist inhalation. The mean (+/-SD) log (postbronchodilator FEV1-prebronchodilator FEV1) values of Gly16 homozygotes (n=65), Arg16Gly16 heterozygotes (n=106), and Arg16 homozygotes (n=75) were 2.19+/-0.43, 2.09+/-0.42, and 2.01+/-0.42, respectively (p<0.05). The genetic effects of the Arg16Gly polymorphism were independent of the severity of airflow limitation, age, and smoking status. The most common Arg16-Gln27 haplotype was also significantly associated with decreased BDRs to salbutamol (p<0.01).

Conclusion

The genetic effects of ADRB2 gene polymorphisms may explain some of the variability in response to therapeutic doses of a short-acting beta2-agonists in patients with COPD."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.org/dc/terms/identifier"doi:10.1378/chest.07-1103"xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/author"Hasegawa M."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/author"Makita H."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/author"Nishimura M."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/author"Nagai K."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/author"Itoh Y."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/author"Hizawa N."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/author"Betsuyaku T."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/author"Nasuhara Y."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/name"Chest"xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/pages"1485-1492"xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/title"Beta2-adrenergic receptor genetic polymorphisms and short-term bronchodilator responses in patients with COPD."xsd:string
http://purl.uniprot.org/citations/17890463http://purl.uniprot.org/core/volume"132"xsd:string
http://purl.uniprot.org/citations/17890463http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17890463
http://purl.uniprot.org/citations/17890463http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17890463
http://purl.uniprot.org/uniprot/#_A2N4T7-mappedCitation-17890463http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17890463
http://purl.uniprot.org/uniprot/#_P07550-mappedCitation-17890463http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17890463
http://purl.uniprot.org/uniprot/#_Q9BYZ0-mappedCitation-17890463http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17890463
http://purl.uniprot.org/uniprot/#_X5DQM5-mappedCitation-17890463http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17890463
http://purl.uniprot.org/uniprot/P07550http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17890463
http://purl.uniprot.org/uniprot/X5DQM5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17890463
http://purl.uniprot.org/uniprot/A2N4T7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17890463
▶