| http://purl.uniprot.org/citations/17893241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17893241 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammals, nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that degrades mRNA harboring a premature termination codon to prevent the synthesis of truncated proteins. To gain insight into the NMD mechanism, we identified NMD inhibitor 1 (NMDI 1) as a small molecule inhibitor of the NMD pathway. We characterized the mode of action of this compound and demonstrated that it acts upstream of hUPF1. NMDI 1 induced the loss of interactions between hSMG5 and hUPF1 and the stabilization of hyperphosphorylated isoforms of hUPF1. Incubation of cells with NMDI 1 allowed us to demonstrate that NMD factors and mRNAs subject to NMD transit through processing bodies (P-bodies), as is the case in yeast. The results suggest a model in which mRNA and NMD factors are sequentially recruited to P-bodies."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200611086"xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/author | "Bertrand E."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/author | "Cougot N."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/author | "Tazi J."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/author | "Durand S."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/author | "Lejeune F."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/author | "Nguyen C.H."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/author | "Grierson D.S."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/author | "Mahuteau-Betzer F."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/pages | "1145-1160"xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/title | "Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies."xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/17893241 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17893241 |
| http://purl.uniprot.org/citations/17893241 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17893241 |
| http://purl.uniprot.org/uniprot/#_P61353-mappedCitation-17893241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17893241 |
| http://purl.uniprot.org/uniprot/#_P61513-mappedCitation-17893241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17893241 |
| http://purl.uniprot.org/uniprot/#_P61927-mappedCitation-17893241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17893241 |
| http://purl.uniprot.org/uniprot/#_O15234-mappedCitation-17893241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17893241 |
| http://purl.uniprot.org/uniprot/#_P49207-mappedCitation-17893241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17893241 |
| http://purl.uniprot.org/uniprot/#_P39019-mappedCitation-17893241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17893241 |
| http://purl.uniprot.org/uniprot/#_P39023-mappedCitation-17893241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17893241 |