| http://purl.uniprot.org/citations/17897941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17897941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17897941 | http://www.w3.org/2000/01/rdf-schema#comment | "Stress conditions inhibit mRNA export, but mRNAs encoding heat shock proteins continue to be efficiently exported from the nucleus during stress. How HSP mRNAs bypass this stress-associated export inhibition was not known. Here, we show that HSF1, the transcription factor that binds HSP promoters after stress to induce their transcription, interacts with the nuclear pore-associating TPR protein in a stress-responsive manner. TPR is brought into proximity of the HSP70 promoter after stress and preferentially associates with mRNAs transcribed from this promoter. Disruption of the HSF1-TPR interaction inhibits the export of mRNAs expressed from the HSP70 promoter, both endogenous HSP70 mRNA and a luciferase reporter mRNA. These results suggest that HSP mRNA export escapes stress inhibition via HSF1-mediated recruitment of the nuclear pore-associating protein TPR to HSP genes, thereby functionally connecting the first and last nuclear steps of the gene expression pathway, transcription and mRNA export."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m704054200"xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m704054200"xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Hong Y."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Hong Y."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Sarge K.D."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Sarge K.D."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Xing H."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Xing H."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Mayhew C.N."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Mayhew C.N."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Murphy L.A."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Murphy L.A."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Skaggs H.S."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Skaggs H.S."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Wilkerson D.C."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/author | "Wilkerson D.C."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/pages | "33902-33907"xsd:string |
| http://purl.uniprot.org/citations/17897941 | http://purl.uniprot.org/core/pages | "33902-33907"xsd:string |