| http://purl.uniprot.org/citations/17901336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17901336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17901336 | http://www.w3.org/2000/01/rdf-schema#comment | "The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d (extended loop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for understanding HIV-1 interactions with the CCR5 N terminus during viral entry and define a conserved site on gp120, whose recognition of sulfotyrosine engenders posttranslational mimicry by the immune system."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1145373"xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1145373"xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Huang C.C."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Huang C.C."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Tang M."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Tang M."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Robinson J."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Robinson J."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Kwong P.D."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Kwong P.D."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Sodroski J."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Sodroski J."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Stanfield R.L."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Stanfield R.L."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Wyatt R."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Wyatt R."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Xiang S.H."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Xiang S.H."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Acharya P."xsd:string |
| http://purl.uniprot.org/citations/17901336 | http://purl.uniprot.org/core/author | "Acharya P."xsd:string |