| http://purl.uniprot.org/citations/17906629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17906629 | http://www.w3.org/2000/01/rdf-schema#comment | "Engagement of antigen receptors triggers the proliferation and functional activation of lymphocytes. Here we report that T cell homeostasis and antigen-induced responses require the COP9 signalosome (CSN), a regulator of the ubiquitin-proteasome system. Conditional deletion of the CSN subunit Csn8 in peripheral T lymphocytes disrupted formation of the CSN complex, reduced T cell survival and proliferation in vivo and impaired antigen-induced production of interleukin 2. Moreover, Csn8-deficient T cells showed defective entry into the cell cycle from the G0 quiescent state. This phenotype was associated with a lack of signal-induced expression of cell cycle-related genes, including G1 cyclins and cyclin-dependent kinases, and with excessive induction of p21(Cip1). Our data define a CSN-dependent pathway of transcriptional control that is essential for antigen-induced initiation of T cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1514"xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/author | "Deng X.W."xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/author | "Chi H."xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/author | "Menon S."xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/author | "Wei N."xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/pages | "1236-1245"xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/title | "COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence."xsd:string |
| http://purl.uniprot.org/citations/17906629 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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