| http://purl.uniprot.org/citations/17906641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17906641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17906641 | http://www.w3.org/2000/01/rdf-schema#comment | "The signaling pathway of nitric oxide (NO) depends mainly on guanosine 3',5'-cyclic monophosphate (cGMP). Here we report the formation and chemical biology of a nitrated derivative of cGMP, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), in NO-mediated signal transduction. Immunocytochemistry demonstrated marked 8-nitro-cGMP production in various cultured cells in an NO-dependent manner. This finding was confirmed by HPLC plus electrochemical detection and tandem mass spectrometry. 8-Nitro-cGMP activated cGMP-dependent protein kinase and showed unique redox-active properties independent of cGMP activity. Formation of protein Cys-cGMP adducts by 8-nitro-cGMP was identified as a new post-translational modification, which we call protein S-guanylation. 8-Nitro-cGMP seems to regulate the redox-sensor signaling protein Keap1, via S-guanylation of the highly nucleophilic cysteine sulfhydryls of Keap1. This study reveals 8-nitro-cGMP to be a second messenger of NO and sheds light on new areas of the physiology and chemical biology of signal transduction by NO."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.org/dc/terms/identifier | "doi:10.1038/nchembio.2007.33"xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.org/dc/terms/identifier | "doi:10.1038/nchembio.2007.33"xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Fujii S."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Fujii S."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Kobayashi A."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Kobayashi A."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Ihara H."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Ihara H."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Okamoto T."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Okamoto T."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Akaike T."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Akaike T."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Sawa T."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Sawa T."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Akuta T."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Akuta T."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Arimoto H."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Arimoto H."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Kim-Mitsuyama S."xsd:string |
| http://purl.uniprot.org/citations/17906641 | http://purl.uniprot.org/core/author | "Kim-Mitsuyama S."xsd:string |