| http://purl.uniprot.org/citations/17908689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17908689 | http://www.w3.org/2000/01/rdf-schema#comment | "Colon cancer is the second leading cause of cancer death in the United States. Krüppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon. It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells. KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood. We found that p300, a CREB-binding protein-related protein, interacts with KLF4 both in vitro and in vivo and activates transcription. We further made the novel observation that endogenous KLF4 is acetylated by p300/CBP in vivo and that mutations of the acetylated lysines resulted in a decreased ability of KLF4 to activate target genes, suggesting that acetylation is important for KLF4-mediated transactivation. Furthermore, we found that KLF4 differentially modulates histone H4 acetylation at the promoters of target genes. Co-transfection of KLF4 and HDAC3 resulted in a synergistic repression of a cyclin B(1) reporter construct. Our results suggest that KLF4 might function as an activator or repressor of transcription depending on whether it interacts with co-activators such as p300 and CREB-binding protein or co-repressors such as HDAC3."xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701847200"xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/author | "Bhakat K.K."xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/author | "Evans P.M."xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/pages | "33994-34002"xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/title | "Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation."xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17908689 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17908689 |
| http://purl.uniprot.org/citations/17908689 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17908689 |
| http://purl.uniprot.org/uniprot/#_B5A210-mappedCitation-17908689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17908689 |
| http://purl.uniprot.org/uniprot/#_B5A211-mappedCitation-17908689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17908689 |
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| http://purl.uniprot.org/uniprot/#_B5A214-mappedCitation-17908689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17908689 |
| http://purl.uniprot.org/uniprot/#_B5A215-mappedCitation-17908689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17908689 |
| http://purl.uniprot.org/uniprot/#_B5A216-mappedCitation-17908689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17908689 |
| http://purl.uniprot.org/uniprot/#_B5A217-mappedCitation-17908689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17908689 |
| http://purl.uniprot.org/uniprot/#_B5A218-mappedCitation-17908689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17908689 |