| http://purl.uniprot.org/citations/17911475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17911475 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-21 (IL-21) is a pleiotropic cytokine whose function is only now being unraveled. Abundant evidence indicates that activated CD4 T cells are the primary, if not the only, source of IL-21. While it is clear that IL-21 is actively transcribed by naïve activated T cells, recent studies have shown that IL-21 potentially promotes a developmental shift of naïve T cells toward the Th2 phenotype. BXSB-Yaa mice develop an autoimmune syndrome similar to systemic lupus erythematosus (SLE), affecting males earlier than females on account of the presence of the Yaa (Y-linked autoimmune acceleration) locus. Previous results indicate the elevation of IL-21 expression by BXSB-Yaa mice at an age when the early characteristics of autoimmune processes first become evident. We set out to determine whether IL-21 was necessary for disease progression in BXSB-Yaa mice. Mice were treated for 24 weeks with soluble IL-21R-Fc in order to therapeutically neutralize the IL-21 present. The results overall suggest a biphasic effect of IL-21, negatively influencing survival early on and positively influencing survival at later stages. We propose that IL-21 exerts a pleiotropic effect in which it promotes the protective effects of CD8+ suppressor cells in the early disease phase and then promotes the humoral components of SLE in the later disease stages. This experiment provides preliminary evidence for a role of IL-21 in modulating the severity of SLE in BXSB-Yaa mice."xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.org/dc/terms/identifier | "doi:10.1196/annals.1423.063"xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/author | "Lyons B.L."xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/author | "Young D.A."xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/author | "Roopenian D.C."xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/author | "Olland S."xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/author | "Bennett S.M."xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/author | "Sproule T.J."xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/author | "Bubier J.A."xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/name | "Ann N Y Acad Sci"xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/pages | "590-601"xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/title | "Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://purl.uniprot.org/core/volume | "1110"xsd:string |
| http://purl.uniprot.org/citations/17911475 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17911475 |
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