| http://purl.uniprot.org/citations/17914460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17914460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17914460 | http://www.w3.org/2000/01/rdf-schema#comment | "Defective Tyrosyl-DNA phosphodiesterase 1 (TDP1) can cause spinocerebellar ataxia with axonal neuropathy (SCAN1), a neurodegenerative syndrome associated with marked cerebellar atrophy and peripheral neuropathy. Although SCAN1 lymphoblastoid cells show pronounced defects in the repair of chromosomal single-strand breaks (SSBs), it is unknown if this DNA repair activity is important for neurons or for preventing neurodegeneration. Therefore, we generated Tdp1-/-mice to assess the role of Tdp1 in the nervous system. Using both in vitro and in vivo assays, we found that cerebellar neurons or primary astrocytes derived from Tdp1-/-mice display an inability to rapidly repair DNA SSBs associated with Top1-DNA complexes or oxidative damage. Moreover, loss of Tdp1 resulted in age-dependent and progressive cerebellar atrophy. Tdp1-/-mice treated with topotecan, a drug that increases levels of Top1-DNA complexes, also demonstrated significant loss of intestinal and hematopoietic progenitor cells. These data indicate that TDP1 is required for neural homeostasis, and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of Top1-associated DNA strand breaks."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601869"xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601869"xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Caldecott K.W."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Caldecott K.W."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Katyal S."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Katyal S."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "McKinnon P.J."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "McKinnon P.J."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Ju L."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Ju L."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Russell H.R."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "Russell H.R."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "el-Khamisy S.F."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/author | "el-Khamisy S.F."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/pages | "4720-4731"xsd:string |
| http://purl.uniprot.org/citations/17914460 | http://purl.uniprot.org/core/pages | "4720-4731"xsd:string |