| http://purl.uniprot.org/citations/17916346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17916346 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA synthesis during S-phase and upon DNA repair is accompanied by chromatin assembly. The chromatin assembly factor CAF-1 has been biochemically well-characterized to deposit histones onto newly synthesized DNA. To gain insights into the in vivo functions of CAF-1 in Drosophila, we generated null mutants of the largest subunit of dCAF-1, dCAF-1-p180. We show that, unlike CAF-1 mutant yeast, dCAF-1-p180 mutant flies are hemizygous lethal. Removal of maternal dCAF-1-p180 activity by germline clones blocks oogenesis. Tissue-specific deletion of dCAF-1-p180 in the eye primordia disrupts eye development. In addition, reduction of dCAF-1-p180 activity suppresses gene silencing at heterochromatin and antagonizes Polycomb-mediated cell fate determination. Furthermore, heterozygous dCAF-1-p180 mutant flies display an increased sensitivity to gamma-irradiation and a reduced efficiency in recombinational double strand break (DSB) repair. Our experiments also show that human hCAF-1-p150 can rescue the dCAF-1-p180 mutant flies, demonstrating a functional conservation of eukaryotic CAF-1 activities in vivo. Together, our results establish that dCAF-1-p180 is an essential gene for Drosophila development and further underscore the importance of dCAF-1 in regulating gene expression and DNA repair in vivo."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2007.08.039"xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "He F."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Liang X."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Song Y."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Xie G."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Stagljar I."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Jiao R."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/author | "Egli D."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/pages | "213-222"xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/title | "CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory."xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://purl.uniprot.org/core/volume | "311"xsd:string |
| http://purl.uniprot.org/citations/17916346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17916346 |
| http://purl.uniprot.org/citations/17916346 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17916346 |
| http://purl.uniprot.org/uniprot/Q9W3D1#attribution-D6E17C84E081DABD519C5DBCC3B0DD6E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17916346 |
| http://purl.uniprot.org/uniprot/Q9W3D1#attribution-F2337B7154FC674EB2F76A816F736A83 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17916346 |
| http://purl.uniprot.org/uniprot/Q8SWV8#attribution-D6E17C84E081DABD519C5DBCC3B0DD6E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17916346 |
| http://purl.uniprot.org/uniprot/Q8SWV8#attribution-F2337B7154FC674EB2F76A816F736A83 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17916346 |