| http://purl.uniprot.org/citations/17921143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17921143 | http://www.w3.org/2000/01/rdf-schema#comment | "Several protein-tyrosine phosphatases (PTPs) have been implicated in the control of growth hormone receptor (GHR) signaling, but none have been shown to affect growth in vivo. We have applied a battery of molecular and cellular approaches to test a family-wide panel of PTPs for interference with GHR signaling. Among the subset of PTPs that showed activity in multiple readouts, we selected PTP-H1/PTPN3 for further in vivo studies and found that mice lacking the PTP-H1 catalytic domain show significantly enhanced growth over their wild type littermates. In addition, PTP-H1 mutant animals had enhanced plasma and liver mRNA expression of insulin-like growth factor 1, as well as increased bone density and mineral content. These observations point to a controlling role for PTP-H1 in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m705814200"xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Clark A."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Xue Y."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Rommel C."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Perrin D."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Hooft van Huijsduijnen R."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Pescini R."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Pilecka I."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Valenzuela D."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Curchod M.L."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Magnone M.C."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Yasenchak J."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Zaratin P."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/author | "Patrignani C."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/pages | "35405-35415"xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/title | "Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth."xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17921143 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17921143 |
| http://purl.uniprot.org/citations/17921143 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17921143 |
| http://purl.uniprot.org/uniprot/#_D3Z7M4-mappedCitation-17921143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17921143 |
| http://purl.uniprot.org/uniprot/#_E9PU89-mappedCitation-17921143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17921143 |