| http://purl.uniprot.org/citations/17921256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17921256 | http://www.w3.org/2000/01/rdf-schema#comment | "Little is known about the tyrosine kinase c-Src's function in the systemic circulation, in particular its role in arterial responses to hormonal stimuli. In human aortic and venous endothelial cells, c-Src is indispensable for 17beta-estradiol (E2)-stimulated phosphatidylinositol 3-kinase/Akt/endothelial NO synthase (eNOS) pathway activation, a possible mechanism in E2-mediated vascular protection. Here we show that c-Src supports basal and E2-stimulated NO production and is required for E2-induced vasorelaxation in murine aortas. Only membrane c-Src is structurally and functionally involved in E2-induced eNOS activation. Independent of c-Src kinase activity, c-Src is associated with an N-terminally truncated estrogen receptor alpha variant (ER46) and eNOS in the plasma membrane through its "open" (substrate-accessible) conformation. In the presence of E2, c-Src kinase is activated by membrane ER46 and in turn phosphorylates ER46 for subsequent ER46 and c-Src membrane recruitment, the assembly of an eNOS-centered membrane macrocomplex, and membrane-initiated eNOS activation. Overall, these results provide insights into a critical role for the tyrosine kinase c-Src in estrogen-stimulated arterial responses, and in membrane-initiated rapid signal transduction, for which obligate complex assembly and localization require the c-Src substrate-accessible structure."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0704315104"xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Sessa W.C."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Baron R."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Collinge M."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Sanjay A."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Bauer P.M."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Bender J.R."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Haynes M.P."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/author | "Hisamoto K."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/pages | "16468-16473"xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/title | "Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation."xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17921256 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17921256 |
| http://purl.uniprot.org/citations/17921256 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17921256 |
| http://purl.uniprot.org/uniprot/#_P63096-mappedCitation-17921256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17921256 |
| http://purl.uniprot.org/uniprot/#_A8MTJ3-mappedCitation-17921256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17921256 |
| http://purl.uniprot.org/uniprot/#_O14775-mappedCitation-17921256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17921256 |
| http://purl.uniprot.org/uniprot/#_P03372-mappedCitation-17921256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17921256 |
| http://purl.uniprot.org/uniprot/#_P16520-mappedCitation-17921256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17921256 |