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http://purl.uniprot.org/citations/17922429http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17922429http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To analyze the polymorphism of HLA-A, B and DR alleles of Duchenne muscular dystrophy (DMD) patients in Han nationality of South China and to discuss the role of immune and genetic factors in the pathogenesis of DMD and muscular fiber necrosis.

Methods

Polymerase chain reaction-reverse sequence specific oligonucleotide (PCR-RSSO) and National Marrow Donor Program (NMDP) were used to analyze the polymorphism of HLA-A,B and DR alleles of 113 DMD patients and 406 normal controls in Han nationality of South China.

Results

The frequencies of HLA-A24, A30 alleles in DMD group were 11.25% and 5.46% respectively, indicating notable difference (P=0.001, < 0.01) from 22.16% and 0.87% of control group; the frequencies of HLA-B13, B15, B61 and B62 alleles in DMD group were 12.26%, 16.92%, 0.44% and 0.44%, indicating a notable difference (P=0.016, < 0.01, 0.001) from 6.76%, 1.49%, 4.79% and 5.05% of control group; the frequencies of HLA-DR04, DR07, DR12 alleles in DMD group were 17.45%, 6.40% and 19.62%, indicating a notable difference (P=0.018, < 0.01, 0.012) from 10.67%, 2.24% and 11.92% of control group.

Conclusion

There are significant differences in the HLA gene frequencies between DMD patients and normal controls. These results suggest that HLA genotype relates to the muscular necrosis and the pathogenesis of DMD."xsd:string
http://purl.uniprot.org/citations/17922429http://purl.uniprot.org/core/author"Chen W."xsd:string
http://purl.uniprot.org/citations/17922429http://purl.uniprot.org/core/author"Zhang C."xsd:string
http://purl.uniprot.org/citations/17922429http://purl.uniprot.org/core/author"Xiao L."xsd:string
http://purl.uniprot.org/citations/17922429http://purl.uniprot.org/core/author"Wu H.L."xsd:string
http://purl.uniprot.org/citations/17922429http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17922429http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/17922429http://purl.uniprot.org/core/pages"567-570"xsd:string
http://purl.uniprot.org/citations/17922429http://purl.uniprot.org/core/title"[Study on correlation between HLA-A, B, DR alleles and Duchenne muscular dystrophy]."xsd:string
http://purl.uniprot.org/citations/17922429http://purl.uniprot.org/core/volume"24"xsd:string
http://purl.uniprot.org/citations/17922429http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17922429
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