| http://purl.uniprot.org/citations/17923499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17923499 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell homeostasis is regulated by multiple signaling processes, including nuclear factor-kappaB (NF-kappaB), BAFF-, and B cell receptor signaling. Conditional disruption of genes involved in these pathways has shed light on the mechanisms governing signaling from the cell surface to the nucleus. We describe a novel mouse strain that expresses solely and excessively a naturally occurring splice variant of CYLD (CYLD(ex7/8) mice), which is a deubiquitinating enzyme that is integral to NF-kappaB signaling. This shorter CYLD protein lacks the TRAF2 and NEMO binding sites present in full-length CYLD. A dramatic expansion of mature B lymphocyte populations in all peripheral lymphoid organs occurs in this strain. The B lymphocytes themselves exhibit prolonged survival and manifest a variety of signaling disarrangements that do not occur in mice with a complete deletion of CYLD. Although both the full-length and the mutant CYLD are able to interact with Bcl-3, a predominant nuclear accumulation of Bcl-3 occurs in the CYLD mutant B cells. More dramatic, however, is the accumulation of the NF-kappaB proteins p100 and RelB in CYLD(ex7/8) B cells, which, presumably in combination with nuclear Bcl-3, results in increased levels of Bcl-2 expression. These findings suggest that CYLD can both positively and negatively regulate signal transduction and homeostasis of B cells in vivo, depending on the expression of CYLD splice variants."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20070318"xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Wallach D."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Kovalenko A."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Galle P.R."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Waisman A."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Fassler R."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Massoumi R."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Bruning J.C."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Strand D."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Wunderlich F.T."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Aumailley M."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Jakobsen C.G."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Merkwirth C."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Hovelmeyer N."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/author | "Worns M.A."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/pages | "2615-2627"xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/title | "Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD."xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/17923499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17923499 |
| http://purl.uniprot.org/citations/17923499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17923499 |