| http://purl.uniprot.org/citations/17926058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17926058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17926058 | http://www.w3.org/2000/01/rdf-schema#comment | "Ankyrin-repeat protein with a PEST motif and a proline-rich region (Arpp), also designated as Ankrd2, is a member of the muscle ankyrin repeat proteins (MARPs), which have been proposed to be involved in muscle stress response pathways. Arpp/Ankrd2 is localized mainly in the I-band of striated muscle. However, it has recently been reported that Arpp/Ankrd2 can interact with nuclear proteins, such as premyelocytic leukemia protein (PML), p53 and YB-1 in vitro. In this study, to determine whether nuclear accumulation of Arpp/Ankrd2 actually occurs, we performed an immunohistochemical investigation of gastrocnemius muscles that had been injured by injection of cardiotoxin or contact with dry ice. We found that Arpp/Ankrd2 accumulated in the nuclei of myofibers located adjacent to severely damaged myofibers after muscle injury. Double-labeled immunohistochemistry revealed that Arpp/Ankrd2 accumulated in the nuclei of sarcomere-damaged myofibers. Furthermore, we found that Arpp/Ankrd2 tended to be localized in euchromatin where genes are transcriptionally activated. Based on these findings, we suggest that Arpp/Ankrd2 may translocate from the I-band to the nucleus in response to muscle damage and may participate in the regulation of gene expression."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00418-007-0348-9"xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00418-007-0348-9"xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Moriyama M."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Moriyama M."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Matsuura K."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Matsuura K."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Uchida T."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Uchida T."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Yano S."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Yano S."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Hijiya N."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Hijiya N."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Tsukamoto Y."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Tsukamoto Y."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Nakada C."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/author | "Nakada C."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/name | "Histochem. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/17926058 | http://purl.uniprot.org/core/name | "Histochem. Cell Biol."xsd:string |