| http://purl.uniprot.org/citations/17928436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17928436 | http://www.w3.org/2000/01/rdf-schema#comment | "The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways depend on GluR1, or other AMPA receptor subunits, for proper synaptic transmission and plasticity, and whether GluR1-dependent long-term potentiation (LTP) is necessary for auditory and contextual fear conditioning. Here, we dissected the role of GluR1 and GluR3 (GluR-C) subunits in AMPA receptor-dependent amygdala LTP and fear conditioning using knock-out mice (GluR1-/- and GluR3-/-). We found that, whereas LTP at thalamic inputs to lateral amygdala (LA) projection neurons and at glutamatergic synapses in the basal amygdala was completely absent in GluR1-/-mice, both GluR1 and GluR3 contributed to LTP in the cortico-LA pathway. Because both auditory and contextual fear conditioning were selectively impaired in GluR1-/- but not GluR3-/-mice, we conclude that GluR1-dependent synaptic plasticity is the dominant form of LTP underlying the acquisition of auditory and contextual fear conditioning, and that plasticity in distinct amygdala pathways differentially contributes to aversive conditioning."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2603-07.2007"xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Sprengel R."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Gebhardt C."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Bosch V."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Johnson A.W."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Jensen V."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Gass P."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Borchardt T."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Humeau Y."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Hvalby O."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Luthi A."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Bannerman D.M."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Reisel D."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/author | "Good M.A."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/pages | "10947-10956"xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/title | "A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning."xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17928436 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17928436 |
| http://purl.uniprot.org/citations/17928436 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17928436 |
| http://purl.uniprot.org/uniprot/#_B0QZW1-mappedCitation-17928436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17928436 |
| http://purl.uniprot.org/uniprot/#_B0QZW2-mappedCitation-17928436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17928436 |